Topic: cortical circuit wiring

Microglia have been shown to provide instructive cues during neuronal development. These cues can impact neural stem and/or progenitor proliferation, neuronal migration, cell death and cortical circuit wiring. Alterations in microglia’s instructive cues have been shown to impact brain development where dysregulation have been linked to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. What then regulates microglia development? Here, we demonstrate that this relationship between neurons and microglia is not unidirectional. Excitatory cells play a similar instructi