Reduced cortical excitability and synaptic proteins in the brain of ApoE deficient mice
Selcen Abidin, Harun Başoğlu, Hilal Öztürk, Yeşim Göçmen, Hüseyin Uydu, İsmail Abidin · FENS Forum 2024
Apolipoprotein E (ApoE) is the major glycoprotein in the brain and plays a critical role in the transport of cholesterol and other lipids. Besides, ApoE has a crucial function in the maintenance of synaptodendritic connections, and repair of neurons. ApoE knockout (ApoE-KO) mice model whose apoE gene has been knocked out has great importance for understanding the effect of ApoE and loss of function of ApoE. Scientists have reported cognitive impairment in ApoE-KO mice, with cholinergic deficits, decreased synaptic excitability. In the present study, we investigated the difference between the b
ePoster · Neuroscience