Hippocampal DNA methylation processes promote memory persistence by facilitating systems consolidation and cortical engram stabilisation
Janina Kupke, Stefanos Loizou, Carsten Sticht, Ana MM Oliveira · FENS Forum 2024
Persistence is a key characteristic of memory that relies on systems consolidation, a process classically defined as the gradual transfer of information from the hippocampus to the cortex for long-term memory storage. However, the underlying molecular mechanisms are unknown. DNA methylation can act as a long-term regulatory signal, therefore being a prime candidate to regulate memory duration and stabilisation within engrams– the physical substrate of a memory.Using contextual fear conditioning (CFC) and engram tagging tools in mice, we showed that reactivation of cortical engrams reflects sys
ePoster · Neuroscience