Topic: Cortical layer I

The marginal zone (MZ) is the most superficial layer of the developing telencephalon which will become cell sparse adult cortical layer I. In this study the MZ in human and cynomologus monkey was examined on Nissl and immunohistochemically processed postmortem fetal brain tissue. From 7 to 13 postconceptional week (pcw) in human, and from embryonic day (E) 46 to 56 in monkey, large cells that express calbindin and calretinin were observed in the MZ, but the overall cell density was exceptionally low. At 15pcw and E64 cell density increased, and small cells that express calretinin, calbindin, s