The role of EEF1A proteins at synapses and in synucleinopathy
Sarka Jelinkova, Lou Bouit, David Perrais, Jochen Herms, Etienne Herzog · FENS Forum 2024
Synucleinopathies (e.g. Parkinson's disease and dementia with Lewy bodies) are neurodegenerative conditions characterized by an accumulation of alpha-synuclein from the prodromal phase. Yet, the pathophysiology is far from being completely understood. We have recently identified the cortical synaptic depletion of eukaryotic elongation factor 1A proteins (EEF1A) at early stages of the disease in a mouse model of synucleinopathy (human alpha-synuclein expressing animals under PDGF promoter specific to various brain tissues, PDGF-hSyn).In order to link EEF1A proteins to synucleinopathy changes, w
ePoster · Neuroscience