A gestational ketogenic diet alters brain wiring and leads to sex-specific and autism-like behavior in the offspring of adult mice
Diana Zala, Lokmane Ludmilla, Bettina Wernisch, Alice Schadde, Hannah Schnoz, Zsolt Lenkei, Renata Santos, Sarah Zala · FENS Forum 2024
Ketosis is a physiological metabolic state, in which fat is the primary energy source (vs glucose), and can be induced through fasting or ketogenic diets (KDs). KDs are rich in lipids and low in carbohydrates, are popular, however, limited literature exists on their safety during pregnancy. Given the essential role of glycolysis in axonal growth dynamics, we hypothesized that KD might disrupt proper axonal guidance during embryonic development, leading to alterations in brain connectivity.Thus, we placed pregnant mice on either a KD or a control diet (CD), starting from gestational day 8.5. KD
ePoster · Neuroscience