Topic: corticofugal projections

Perception of vocalizations is critical for many species. In mammals, the central auditory pathway is highly interconnected, with corticofugal feedback projections from auditory cortex (AC) to the auditory midbrain that rival the density of feed-forward auditory input. These projections support sound localization, feature coding, and noise invariance. Because vocalizations are acoustically complex and carry social significance, we hypothesize that feedback projections from AC enable behavioral responses. Infant vocalizations that elicit parental care are highly conserved in mammals. In mice, e