Topic: corticospinal assembloids

The corticospinal tract is a complex system of paramount importance for the control of voluntary movements. It originates in the cerebral cortex from upper motor neurons which directly contact the lower motor neurons located in the ventral horns of the spinal cord. Lower motor neurons, in turn, form synapses with skeletal muscle cells delivering the signal generated in the brain. Insults to this system, such as spinal cord injuries or amyotrophic lateral sclerosis, cause dysfunction and degeneration of motor neurons leading to severe and untreatable pathological conditions. We aim to explore t