Effects of early exposure to NMDA receptor NR1-specific antibodies on the developing mouse striatum
Anezka Macey-Dare, Danijela Bataveljic, Tommas Ellender · FENS Forum 2024
Anti-NMDA receptor (NMDAR) encephalitis is associated with the presence of autoantibodies against subunit 1 of the NMDA receptor (NR1) resulting in a variety of psychiatric symptoms as well as cognitive and motor impairments. These autoantibodies can arise in adulthood but also during pregnancy where they have been shown to affect the developing foetal brain and are implicated in neurodevelopmental disorders including autism and learning disabilities. Binding of these autoantibodies causes internalization of surface NMDAR leading to their reduced expression and disrupted signalling. To what ex
ePoster · Neuroscience