Topic: corticothalamic networks

Absence seizures are classified as genetic generalized seizures. They arise from abnormalities in corticothalamic networks evident as spike-wave discharges on electroencephalograms. Altered gamma-aminobutyric acid (GABA) neurotransmission is commonly reported in rodent models for absence seizures. However, the underlying causative mechanism for seizures at the cellular and molecular level is debated and appears multifactorial, which may account for the variable efficacy of antiepileptic drugs. Current drugs fail to suppress seizures in over 30% of children with absence epilepsy. Previously, we