Selective modulation of the infralimbic cortex activity regulates reinstatement of cocaine-context associations in mice
Ana M. Pérez-Cano, José M. Pérez-Berlanga, Fabiola Ávila-Gámiz, Luis Javier Santín, David Ladrón de Guevara-Miranda · FENS Forum 2024
Mechanisms underlying relapse into cocaine are not yet fully understood. Animal studies suggest a pivotal involvement of the infralimbic (IL) division of the medial prefrontal cortex, but causal evidence is lacking. Here, we employed chemogenetics to selectively modulate the IL during reinstatement of cocaine-related behaviours in the conditioned place preference (CPP) model. To this aim, C57BL/6J mice (N = 28) received intra-IL microinjections of adeno-associated viral vectors containing either silencing (AAV5-CaMKIIα-hM4Di-mCherry) or stimulatory (AAV5-CaMKIIα-hM3Dq-mCherry) designer recepto
ePoster · Neuroscience