Topic: CR cell ablation

The hippocampus is a brain structure renowned for its role in memory formation, learning and the representation of space. Hippocampal circuitry is comprised of a diverse set of excitatory and inhibitory neurons, including a transient population of reelin+ glutamatergic Cajal-Retzius neurons (CR). In contrast to neocortical CR-cells, which disappear soon after birth, hippocampal CR-cells persist for an extended period during postnatal development. These CR-cells are actively integrated into the hippocampal microcircuit; however, their influence on postnatal hippocampal development and function