Cellular specificity and sexual dimorphism of hippocampal CB1 receptors on behavioral processes
Lucía Sangroniz-Beltrán, Nicolas Landgraf, Andrés Baraibar, María Ceprián, Juan Cobos, Francisca Julio-Kalajzic, Pablo Alejandro Reyes Velásquez, Itziar Bonilla, Nagore Puente, Almudena Ramos, Giovanni Marsicano, Pedro Grandes, Susana Mato, Jon Egaña-Huguet, Edgar Soria-Gómez · FENS Forum 2024
In this work, we want to dissect the specific and sex-dependent role of CB1 signalling in different cell types and its impact on hippocampal functions such as navigation or memory. A specific Cre-mediated CB1 deletion on neurons (excitatory and inhibitory), astrocytes, or interneurons in CB1-flox males and females was performed. Viral vectors (AAV-Cre) were injected bilaterally into the hippocampus of these mice. The Barnes maze was used for learning, memory, navigation and the Novel Object Recognition Test (NORT) for recognition memory. Anxiety-like behavioural protocols were also performed b
ePoster · Neuroscience