The effects of CRF agonists and antagonists on the noradrenaline released from the locus coeruleus and the serotonin released from the raphe nuclei
Zsolt Bagosi, Patrícia Tancsics, Chiara Horváth, Eszter Nasim Madani, Éva Bodnár, Katalin Eszter Ibos, Krisztina Csabafi · FENS Forum 2024
Corticotropin-releasing factor (CRF) and the urocortins (UCN1, UCN2 and UCN3) are structurally related neuropeptides which act via two CRF receptors (CRF1 and CRF2) with putatively dualistic actions in the brain. The aim of the present study was to investigate the effects of CRF agonists, such as CRF, UCN1, UCN2, and UCN3, and CRF antagonists, such as antalarmin (a selective CRF1 antagonist) and astressin2B (a selective CRF2 antagonist) on the release of noradrenaline (NA) in the locus coeruleus (LC) and serotonin (5HT3) in the raphe nuclei (RN). For this purpose, male Wistar rats were used, t
ePoster · Neuroscience