Intranasal CRHR2 agonist administration may affect negative outcome of PTSD in animal model
Andrej Tillinger, Alexandra Zvozilová, Mojmír Mach, Jana Osacká · FENS Forum 2024
Post-traumatic stress disorder (PTSD) is a multifaceted psychological disorder characterized by deregulated fear and stress responses. Etiology and progression of PTSD involve multiple neurochemical factors that interact in complex ways and consequently alter range of neurotransmitters systems. One of the most important is CRH system, which involvement in fear and stress response is well established. CRH acts through two receptors, CRHR1 that plays role in stress responding and anxious arousal and CRHR2 that is responsible for dampening the stress response initiated by activation of CRHR1. In
ePoster · Neuroscience