ePoster · Neuroscience
Development of iPSC-derived neural progenitor cells with enhanced migration to stroke tissue and inducible ablation systems
Beatriz Achón Buil, Rebecca Z. Weber, Nora H. Rentsch, Carmen Helfenstein, Ruslan Rust, Christian Tackenberg · FENS Forum 2024
Stem cell therapy has emerged as a promising strategy for treating stroke, but it still presents several challenges, such as the optimal administration route or safety concerns. In clinical practice, endovascular delivery of cells is preferred to intracerebral injection. However, circulating stem cells must cross the blood-brain barrier (BBB) and might get trapped in peripheral organs, resulting in an insufficient number of cells reaching the lesion. To optimize their migration across the BBB, we aimed to mimic immune cells as they extravasate into the brain parenchyma following injury. For in