Topic: CRISPR-based epigenetic editing

With their Janus-faced property of being at once dynamic and stable, epigenetic mechanisms have for long been proposed to act as potential molecular mnemonics, but a cell type-specific, locus-restricted and temporally controllable interrogation thereof has thus far been lacking. Over the past years, accumulating evidence has shown that memories are likely encoded in sparse populations of brain cells, so-called engrams, which have, with a few exceptions, received little molecular attention. Here, we combine c-Fos driven engram tagging technologies with CRISPR-based epigenetic editing in vivo to