Investigating synaptic dysfunction caused by AMPA receptor trafficking to lysosomes in familial Alzheimer’s disease iPSC-derived neurons
Anne Dewitz, Jonathan Hanley · FENS Forum 2024
Synaptic dysfunction in response to amyloid-beta (Aß) accumulation is increasingly recognized as a precursor of cognitive decline in Alzheimer's Disease (AD). AMPA receptors (AMPARs), the major neurotransmitter receptors in the brain, are implicated in the synaptic dysfunction observed in rodent models expressing amyloidogenic APP mutations. AMPARs are proposed to undergo aberrant trafficking, characterized by changes in their subunit composition and subcellular localization. The precise mechanisms underlying the dysregulation of AMPAR trafficking in AD remain poorly understood.Here, we apply
ePoster · Neuroscience