“Universal (EPO, EV-3, TPO, …)” cytokine-mediated neuroprotection via phylogenetically ancient cytokine receptor-like factor 3 (CRLF3)
Ralf Heinrich, Björn Twellsieck, Nicola Schwedhelm-Domeyer, Stephanie Pauls, Debbra Knorr · FENS Forum 2024
Cytokine receptor-like factor 3 (CRLF3) is an phylogenetically ancient class 1 cytokine receptor present in all major eumetazoan taxa ranging from cnidarians to mammals. In humans, CRLF3 is expressed in various tissues and has been associated with proliferation, differentiation, cell survival and some diseases. Our studies on insect neurons and human iPSC-derived neurons demonstrated that CRLF3 (whose insect-endogenous ligand is still unidentified) can be activated by human erythropoietin (EPO) and its non-erythropoietic splice variant EV-3. Under apoptogenic conditions, CRLF3 initiates pro-su
ePoster · Neuroscience