ePoster · Neuroscience
Maintenance of the timing information in olfactory working memory by global activity waves
Xiaoxing Zhang, Ermeng Huang, Huangao Zhu, Da Xu, Zhaoqin Chen, Yulei Chen, Chengyu Li · COSYNE 2023
Sun, Mar 12, 2023
Working memory (WM) retains information during delay periods. How global neuronal activities maintain WM remains unclear. We recorded brain-wide activity via Neuropixels in mice performing a delay-varying olfactory WM task, to reveal animal’s capacity in maintaining both olfaction and duration information simultaneously. Neurons encoded WM information predominantly in transient patterns and generated cross-region activity waves, reflecting distinct cell assemblies that encoded olfaction-only, duration-only, or both information. The regional proportion of neurons and wave timing within cell ass