Topic: cross-species differences

Inhibitory interneurons in cortex consist of many subtypes that differ in, e.g., connectivity and physiology. Recently, it was shown that —in layers 1-3 of mouse primary visual cortex— interneuron subtypes differ systematically in their modulation with an animal’s behavioural state, and that this state modulation can be predicted from the first principal component (PC) of the gene expression matrix (Bugeon et al. 2022). Here, we ask if this link between transcriptome and state-dependent processing is a general principle that extends across layers, areas, and species. To this end, we analysed