Topic: CRTC1

CREB-regulated transcription coactivator 1 (CRTC1) plays a pivotal role in regulating the expression of genes involved in neuronal survival, synaptic plasticity, and long-term potentiation by interacting with cAMP response element-binding protein (CREB). Our research utilizes a Crtc1 knockout (KO) mouse model, which exhibits increased aggressiveness, depressive-like behavior, and obesity in males. The bidirectional relationship between obesity and major depressive disorder (MDD) is well-established, with both conditions linked to elevated neuroinflammatory markers in various brain regions. CRT