Topic: cryo-tomograms

Neurons communicate at specialized terminals called synapses, where hundreds of molecules work together in harmony to ensure proper and efficient signal transmission, which is crucial for normal brain functions. Aberrant synaptic signalling is involved in many neurodevelopmental and neurodegenerative diseases such as autism and Parkinson’s disease. This highlights the need to understand the organization and interactions of molecular complexes at the synapse. Cryo-electron tomography (cryo-ET) offers a close-to-native preservation of biological specimen and the unique possibility to capture bot