Topic: CSF-blood barrier

The choroid plexus produces cerebrospinal fluid (CSF) by transporting ions and water from adjacent blood vessels to the brain ventricles. The choroid plexus plays additional roles in brain development and homeostasis by secreting neurotrophic molecules and serving as a CSF-blood barrier and immune interface. Previous studies highlighted that several transporters on the epithelial cells transport water and ions into the ventricles and tight junctions of the cells are involved in the CSF-blood barrier. Yet, how the choroid plexus epithelial cells maintain the brain ventricle system and influence