Topic: CSF clearance

Lymphatic vessels and veins are closely associated in the dura mater around the venous sinuses, but how much venous outflow can influence the structure and function of dural lymphatics remains unknown. To investigate this vein-lymphatic interaction we developed a mouse model of cerebral venous outflow obstruction. Using postmortem and live imaging, we observed that glymphatic-lymphatic coupling is depending on venous drainage from the cranium and that lymphatic drainage impairment arises under conditions of venous drainage dysfunction. Long-lasting immune cell recruitment was also observed in