Topic: CSF flow

Cerebrospinal fluid (CSF) is integral to brain architecture, providing mechanical and nutritional support to the tissue while clearing metabolic waste. Recent research reveals its potential role in neuromodulation through its transport of various signaling molecules. Yet, to what extend CSF impacts the direct delivery of such molecules is poorly understood. CSF circulation is tightly regulated by a combination of factors such as cardiac activity, glial regulation, and notably, ciliary beating of ependymal cells lining the brain ventricles. Ciliary dysfunction, as observed in ciliopathies, ofte