Microglia display a bi-phasic effect in amyloidosis
Nora Baligacs, Sriram Balusu, Giulia Albertini, Bart De Strooper · FENS Forum 2024
Identification of Alzheimer's disease (AD) risk loci highlighted the role of microglia in the pathogenies of AD. Nevertheless, whether microglia are beneficial or detrimental in AD is still debated. Several studies tested the contribution of microglia to amyloid pathology by microglia depletion, resulting in seemingly contradictory results. Here, we aimed to unify these conflicting findings by systematically testing microglia depletion at various stages of disease progression in mice.Depletion of microglia by PLX3397 treatment before the onset of amyloid plaques in AppNL-G-F mice resulted in a
ePoster · Neuroscience