KLHL14-Cre as a novel tool for investigation and manipulation of axon targeting and innervation by bulbar-cervical corticospinal neurons
Alexander Lammers, Jake Lustig, Payal Patel, Julia Kaiser, Phong Nguyen, James Conner, Eiman Azim, Vibhu Sahni · FENS Forum 2024
The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that corticospinal neurons (CSN) establish segmentally specific connectivity with spinal circuitry. Recent work has identified CSN-intrinsic molecular determinants that regulate CSN axonal projections to specific segmental levels of the neuraxis and that these are expressed by CSN subpopulations that project to distinct levels of the neuraxis. In the present study, we establish the use of a newly generated Klhl14-T2A-Cre knock-in reporter mouse line to investigate axonal projections of a specific CSN subpo
ePoster · Neuroscience