Topic: cuprizone-induced demyelination

Myelin, produced by oligodendrocytes (OLs), is a lipid-rich structure that wraps axons, facilitating the saltatory conduction and providing metabolic support to neurons. Myelin is a highly adaptable structure whose role in regulating synaptic transmission in the healthy and diseased brain have not been extensively examined and may be relevant for understanding neuronal dysfunctions associated with myelin-related disorders. Here, we investigated excitatory (EPSCs) and inhibitory (IPSCs) post-synaptic currents in layer IV of the somatosensory (barrel) cortex using a cuprizone-induced demyelinati