Exploring the role of omega-3/omega-6 balance in long-lasting changes in microglia caused by intermittent alcohol consumption during adolescence
Garazi Ocerin, Imanol González-Burguera, Miquel Saumell-Esnaola, Maitane Serrano, Itziar Bonilla-Del Río, Xabier Aretxabala, Almudena Ramos-Uriarte, Leire Reguero, Inmaculada Gerrikagoitia, Nagore Puente, Gontzal García del Caño, Pedro Grandes · FENS Forum 2024
Alcohol raises concerns due to the episodic and intense alcohol intake observed in adolescents. Recent studies reveal a correlation between escalated EtOH intake and neuroinflammation, emphasizing the endocannabinoid (eCB) system´s engagement. Our previous data in mice revealed that intermittent EtOH-exposure during adolescence leads to elevated levels of the ω-6 arachidonic acid (AA) in adulthood. AA is intricately linked to the neuroinflammatory response as a precursor of proinflammatory prostaglandins, and its brain levels are intertwined with balance between the synthesis and hydrolysis of
ePoster · Neuroscience