Microglia-specific circadian rhythm disruption leads to an altered inflammatory profile and increased susceptibility to seizures
Tammy Strickland, Radharani Benvenutti, Yiyue Jiang, Melissa Alves Braga de Oliveira, Mona Heiland, Annie Curtis, David Henshall, Cristina R Reschke · FENS Forum 2024
Background: Epilepsy and seizures occurrence are closely interwoven with brain inflammation. The inflammatory response is largely mediated by microglia, which are under strong circadian regulation. Circadian rhythms are 24-hour variations in physiological function orchestrated by a network of autoregulatory genes, including its key component, Bmal1. Here we explored the impact of Bmal1 knock down in microglial cells on seizure susceptibility and the CNS-immune profile.Methods: Forty young adult Bmal1-Cx3CR1Cre-ER mice were injected with either tamoxifen (40 mg/kg; IP; daily for 10 days) to ind
ePoster · Neuroscience