3-Photon in vivo imaging reveals breakdown of microglia surveillance upon glioma invasion in the corpus callosum
Felix Nebeling, Falko Fuhrmann, Manuel Mittag, A Deli, Miriam Stork, Melanie Clements, Claudia Garcia Diaz, Simona Parrinello, Paolo Salomoni, Ulrich Herrlinger, Martin Fuhrmann · FENS Forum 2024
Glioblastomas (GB) are the most malignant primary brain tumors with median survival of about 17 month despite extensive treatment. Molecular heterogeneity and the tumor microenvironment contribute to the challenges in treating GBs. Glioma-associated microglia and macrophages, comprising 30-50% of non-neoplastic cells in the microenvironment, play a crucial role in facilitating tumor growth and inducing tissue necrosis. However, the intricate interplay between these immune and glioma cells remains poorly understood.This study focuses on understanding the dynamic role of microglia during gliobla
ePoster · Neuroscience