ePoster · Neuroscience
Design, synthesis and pharmacological evaluation of pyrazole/tacrine derivatives as potential acetylcholinesterase inhibitors
Jelena Penjišević, Mihajlo Krunić, Deana Andrić, Slađana Kostić-Rajačić, Vladimir Šukalović, Ivana Jevtić · FENS Forum 2024
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the elderly inviduals, with a prevalence twice as high in the female population. [1] Acetylcholine inhibitors (AChEIs) are one of the most investigated class of chemical compounds in treatment of AD. As a part of our ongoing research in AChEIs development, we designed and synthesized four novel compounds (4a-d) that contain tacrine moiety as AChE pharmacophore. Tacrine derivatives are particularly interesting in this area of research, due to the high inhibitory activity towards AChE. Ne