Investigating the role of pyramidal cells in the neurovascular uncoupling of Alzheimer's disease
Esther Belzic, Benjamin Le Gac, Bernadette Hannesse, Marie-Pierre Morel, Sandrine Picaud, Dongdong Li, Bruno Cauli · FENS Forum 2024
Neurovascular coupling (NVC), the tight coupling between neural activity and cerebral blood flow (CBF), is essential for brain function and integrity. Decreased CBF and altered NVC are among the earliest biomarkers of Alzheimer’s disease (AD) and may exacerbate its progression. Among the various cellular players of NVC, cyclooxygenase-2 (COX2) pyramidal cells, play a key role via the release of prostaglandin E2 (PGE2), which can bidirectionally control the NVC. We investigated the role of pyramidal cells in neurovascular uncoupling of AD using cortical slices from triple transgenic mice expres
ePoster · Neuroscience