CYFIP1 associates with astrocytic focal adhesion, distinct from CYFIP2: Analysis of protein interactome and cellular expression profiling
Ruiying Ma, Kaifang Pang, Hyojin Kang, Yinhua Zhang · FENS Forum 2024
Cytoplasmic FMR1-interacting protein family contains two members, CYFIP1 and CYFIP2, evolutionarily conserved multifunctional proteins. Despite their high sequence homology, varied evidence indicates that CYFIP1 and CYFIP2 have distinct functions in vivo and are linked to different brain disorders. However, the underlying mechanisms remain largely unknown.We conducted reciprocal immunoprecipitation experiments to explore the underlying mechanisms using CYFIP1-2×Myc and CYFIP2-3×Flag knock-in mice. The results revealed that CYFIP1 and CYFIP2 are not significantly co-immunoprecipitated with each
ePoster · Neuroscience