CYP2C19 in the developing brain of transgenic humanized knock-in mouse causes morphological changes in the cerebellum, including 11.8% atrophy
Andrea Atanasov, Filip Milosavljević, Irene Brusini, Marina Manojlović, Pavle Sitarica, Chunliang Wang, Peter Damberg, Magnus Ingelman-Sundberg, Marin Jukić · FENS Forum 2024
CYP2C19 is mainly, a liver enzyme that metabolizes psychotropic compounds, however, it is also expressed in the fetal brain. Transgenic knock-in mice carrying the human CYP2C19 gene show the same expression pattern of this enzyme as humans. This study aims to characterize the motor function and brain morphological phenotype of CYP2C19 transgenic mice. Experiments were performed in CYP2C19 transgenic mice with wild-type littermates as controls, in both sexes. Maximal hind paw elevation while walking was measured from video recordings of the footprint test. Structural T1-weighted MRI scans were