Neurodegeneration risk factors’ interplay: Characterization of APOE3 and APOE4 genotype upon chronic inflammation
Séfora Barberà Parada, Judit Biosca-Brull, Raquel Gabaldón-Díaz, Rocío Rodulfo-Cárdenas, Maria Cabré, Jordi Blanco, Maria Teresa Colomina · FENS Forum 2024
The human APOE4 genotype has been identified as a crucial risk factor for developing neurodegenerative diseases, such as Alzheimer, in elderly. However, no clear directions to generate a prevention plan for APOEε4 carriers exist nowadays. In this sense, current knowledge states that chronic neuroinflammation is a convergent point to neural diseases, contributing to neurodegeneration. Interestingly, APOE is an immunomodulatory agent, establishing a nexus between those premises. However, mechanisms underlying this association are yet to be clarified.We aimed to identify in aged transgenic mice t
ePoster · Neuroscience