Presynaptic Activity-dependent calcium dynamics in cytosol & ER, and a brief proposal for a morphodynamic model of growth cone motility
Nicole Flores-Pretell, Ranjita Dutta Roy, Daniel Gonzalez-Esparza, Dmitry Logashenko, Markus Breit, Markus Knodel, Gabriel Wittum · Bernstein Conference 2024
Understanding the mechanisms regulating Ca2+ concentrations in the presynapse is crucial for synaptic function. The endoplasmic reticulum (ER) acts as a finite calcium store and can modulate calcium signals involved in presynaptic neurotransmitter release. While computational studies have shed light on the spatiotemporal dynamics of calcium in dendritic spines, the distribution of channels along synaptic and ER membranes and their modulation of calcium dynamics remain unclear. We investigated the influence of calcium exchange in different spatial compartments and the dynamics of calcium concen