Changes in neurotransmitter activity in septo-hippocampal network in naturally aged rats and a rat model of aging induced by D-galactose administration: Relationship with memory impairment
Ekaterine Kipiani, Maia Burjanadze, Gela Beselia · FENS Forum 2024
D-galactose-injected rodent models recapitulate many features of brain aging. The alterations in the septo-hippocampal network associated with memory decline in rat model of aging induced by D-galactose (D-gal) administration are not defined. The present study was designed to determine changes in the number of cholinergic (choline acetyltransferase immunoreactive – ChAT-ir) and GABAergic (parvalbumine immunoreactive – PV-ir) medial septum (MS) projection neurons and the hippocampal cholinergic activity and how these changes are associated with mnemonic dysfunction in a rat model of aging induc
ePoster · Neuroscience