Dopamine and glutamate receptor heteromers as a common molecular substrate for substance use disorder and comorbid depression
Marie-Charlotte Allichon, Vanesa Ortiz, Paula Pousinha, Faustine Arrivet, Andry Andrianarivelo, Joszef Meszaros, Alexis P Bemelmans, Naguib Mechawar, Gustavo Turecki, Jonathan Javitch, Nicolas Heck, Sébastien Parnaudeau, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte · FENS Forum 2024
Drug addiction is a psychiatric disorder defined as a compulsive pattern of drug-seeking/taking behaviors, with recurrent episodes of abstinence and relapse. Addictive drugs increase dopamine in the nucleus accumbens (NAc), where it persistently shapes excitatory glutamate transmission, thereby hijacking natural reward processing. Recently, we provide evidence, from mice to humans, that psychostimulants and opiates alter DA-glutamate signal integration in the NAc through a drug-evoked heteromerization (i.e direct physical interaction) of glutamate NMDA receptors (NMDAR) with D1R or D2R. Using
ePoster · Neuroscience