Implication of mesocorticolimbic dopamine transmission in goal-directed behaviors: A role for dopamine and NMDA receptor heteromers?
Anna Petitbon, Andrea Contini, Roman Walle, Maria-Florencia Angelo, Marie-Charlotte Allichon, Lola Hardt, Maewenn Cazala, Mélanie Depret, Javier Correa Vazquez, Rodrigue Ortole, Romain Thebeaud, Amélie Blanc, Maï Rousseaud, Andry Andrianarivelo, Jacques Barik, Peter Vanhoutte, Pierre Trifilieff · FENS Forum 2024
Executive function impairments are a common symptom of many psychiatric pathologies. They are correlated with impaired dopaminergic transmission originating from the midbrain within the medial prefrontal cortex (mPFC), and subcortical areas such as the nucleus accumbens (NAc). This mesocorticolimbic dopamine transmission is believed to be a key modulator of goal-directed behaviors and reward processing through its action on dopaminoceptive neurons expressing either D1 (D1R) or D2 receptors (D2R) in those target structures. However, the precise mechanisms by which this transmission enables an i
ePoster · Neuroscience