Dopamine D3 receptor blockade enhances hippocampal plasticity through post-synaptic mechanisms
Maria Rosaria Tropea, Marcello Melone, Domenica Donatella Li Puma, Valeria Vacanti, Giuseppe Aceto, Bruno Bandiera, Roberta Carmela Trovato, Sebastiano Alfio Torrisi, Gian Marco Leggio, Agostino Palmeri, Marcello D'Ascenzo, Fiorenzo Conti, Claudio Grassi, Daniela Puzzo · FENS Forum 2024
Dopamine D3 receptors (D3Rs) regulate several brain functions such as reward and social behavior by modulating neuronal activity in different brain regions. Although mostly expressed in dopaminergic areas, D3Rs are also present in the hippocampus. Previous results obtained in our laboratory suggested that D3 pharmacological blockade or genetic deletion in D3-knock-out (KO) mice enhanced hippocampal long-term potentiation (LTP) and memory. Based on these findings, here, we aimed to explore the molecular bases underlying this pro-cognitive effect.To determine whether D3R blockade acted via pre-
ePoster · Neuroscience