Convergent regulation of dopamine release by striatal dopamine transporters and GABA receptors
Bethan O'Connor, Emanuel F. Lopes, Lucille Duquenoy, Yukun A. Hao, Sungmoo Lee, Michael Z. Lin, Katherine R. Brimblecombe, Stephanie J. Cragg · FENS Forum 2024
Dopamine (DA) transmission plays a key role in reward, motivation, and action selection, and becomes dysregulated in substance-use disorders and Parkinson’s disease. Midbrain DA neurons form vast axonal arbours in the striatum, presenting opportunities for local axonal regulation of DA signalling by diverse interacting mechanisms. Striatal DA transporters (DATs) and γ-aminobutyric acid receptors (GABA-Rs) are both thought to limit DA axon activation and thereby attenuate DA release probability whilst also supporting the frequency-dependence of DA release. We tested whether these convergent mec
ePoster · Neuroscience