Ryanodine receptors modulate synaptic transmission and non-L type calcium channels in mouse hippocampal neurons and adrenal chromaffin cells
Enis Hidisoglu, Giuseppe Chiantia, Orhan Erkan, Giulia Tomagra, Claudio Franchino, Valentina Carabelli, Emilio Carbone, Andrea Marcantoni · FENS Forum 2024
Calcium released from intracellular stores is critical for controlling cellular processes such as secretion, synaptic transmission, and gene expression. Ryanodine receptors (RyRs) are Ca2+-permeable channels found in the endoplasmic reticulum. Currently, the relationship between Ca2+-induced Ca2+release (CICR) via RyRs and Ca2+-dependent synaptic transmission is unclear. Here, we investigated the role and potential mechanisms of RyR-mediated Ca2+ release at excitatory synapses. Experiments were performed on mouse hippocampal autaptic neurons (hANs) and adrenal chromaffin cells (CCs). The analy
ePoster · Neuroscience