Cortical inactivation of Darpp-32 impairs synaptic and structural plasticity associated with motor learning
Clarissa Pisanò, Alina Aaltonen, Ayu Tamaki, Valeria Spanu, Gilberto Fisone, Emanuela Santini, Anders Borgkvist · FENS Forum 2024
Aim: Motor learning significantly impacts daily life, triggering notable changes in the primary motor cortex (M1) and basal ganglia (BG). Dopamine (DA) mediates these changes, with Darpp-32 playing a key role in DA transmission. Although extensively studied in the BG's striatum, Darpp-32's function in the motor cortex remains largely unexplored. This study aims to characterize Darpp-32 in motor cortices, examining cellular expression and its impact on motor behavior, synaptic and structural plasticity.Methods: Anatomical study: Using C57BL/6 mice, we examined Darpp-32 distribution across corti
ePoster · Neuroscience