Mouse model of dopamine transporter-associated parkinsonism and co-morbid psychiatric disease
Freja Herborg, Lisa Konrad, Søren H. Jørgensen, Jamila Lilja, Ciara Pugh, Benoît Delignat-Lavaud, Cecilia Friis Ratner, Nora Awadallah, Jose A. Pino, Freja Berlin, Mathias Rickhag, Birgitte Holst, David Woldbye, Gonzalo Torres, Louis-Eric Trudeau, Ulrik Gether · FENS Forum 2024
Dysfunctional dopaminergic neurotransmission is implicated in several pathologies, including movement disorders such as parkinsonism and psychiatric diseases, suggesting overlapping pathological mechanisms. The dopamine transporter (DAT) is a key regulator of dopamine signalling and rare disease-associated DAT variants can cause psychiatric diseases and early-onset parkinsonism. However, the pathobiological processes that link DAT dysfunction to both parkinsonism and psychiatric symptoms are unknown. To investigate this, we developed a novel mouse disease model that expresses two mutations in
ePoster · Neuroscience