Structural and functional alterations in the retina of a model of Alzheimer’s disease and type 2 diabetes
Angel del Marco, Santiago Milla-Navarro, Karis Little, Maria Llorián-Salvador, Fátima Cano-Cano, Rafael Simó, Alan W Stitt, Pedro de la Villa, Monica Garcia-Alloza · FENS Forum 2024
The retina, as part of the central nervous system, shows abnormalities in Alzheimer`s disease (AD) and type 2 diabetes (T2D). Importantly, analysis of the retina may provide a non-invasive approach with diagnostic and prognostic value for cognitive decline. In addition, T2D increases risk to suffer AD. Accordingly, we have analyzed structural and functional alterations, by spectral domain optical coherence tomography and electroretinography (ERG) respectively, in the retina from APP/PS1 (AD model), db/db (T2D model) and APP/PS1xdb/db (AD-T2D model) animals at 4 weeks of age, before the onset o
ePoster · Neuroscience