Different dopaminergic mechanism in the expression of sign-tracking phenotype in C57BL/6J and DBA/2J mice
Andrea Sepe, Valeria Tarmati, Cristina Orsini, Simona Cabib · FENS Forum 2024
Aims: Sign-tracking (ST) behavior is a phenotype characterized by attraction to a reward-associated stimulus due to incentive salience attribution and it’s considered an endophenotype of vulnerability to drug addiction. Such phenotype is dependent on Dopamine (DA) transmission within the Nucleus Accumbens core (NACc), as DA suppression prevents both its development and expression. However, previous studies suggested the hypothesis that ST behavior can be dependent on different neural mechanisms in two inbred strains of C57BL/6J (C57) and DBA/2J (DBA) mice, which have known differences in their
ePoster · Neuroscience