Cognitive disturbances after hearing loss in adult rats are not accompanied by altered NeuN-, GABA-, and dopamine-expression in the central auditory pathway and prefrontal cortex
Marla Sofie Witte, Mariele Stenzel, Mesbah Alam, Jonas Jelinek, Joachim K. Krauss, Kerstin Schwabe, Marie Johne · FENS Forum 2024
Hearing loss in the elderly has been associated with cognitive impairments and an increased risk of dementia. Social withdrawal due to difficulties in verbal interaction may play an important role. Previous research on deafened rats, ruling out language as a potential confounding factor, showed only initial and mild cognitive deficits during learning, whereas electrophysiological recordings in the prefrontal cortex revealed compromised neuronal activity to some extent. The present study tested whether hearing loss would lead to altered expression of the GABA and dopamine (DA) systems in key re
ePoster · Neuroscience