Methylcobalamin promotes angiogenesis after peripheral nerve injury
Yoshiaki Yoshimura, Toru Iwahashi, Toshiki Shimada, Katsuyuki Konishi, Atsushi Kamata, Mai Konishi, Arisa Kazui, Ryoya Shiode, Satoshi Miyamura, Kunihiro Oka, Seiji Okada, Hiroyuki Tanaka · FENS Forum 2024
Aims: To investigate the effects of methylcobalamin (MeCbl) on angiogenesis after peripheral nerve injury.Methods: For in vivo experiments, we used eighteen 6-week-old male Wistar rats. The left sciatic nerve was excised and bridged using the decellularized nerve. Then, rats were randomly divided into MeCbl treated and saline treated groups. At postoperative 7 days, nerves were harvested and evaluated for immunohistochemistry. For in vitro experiments, scratch assay, and tube formation assay were evaluated in the presence or absence of MeCbl using human umbilical vein endothelial cells. Additi
ePoster · Neuroscience